منابع مشابه
Mending a Faltering Heart.
More people die every year from ischemic heart disease than any other disease. Because the human heart lacks sufficient ability to replenish the damaged cardiac muscles, extensive research has been devoted toward understanding the homeostatic and regenerative potential of the heart and to develop regenerative therapies for heart disease. Here, we discuss recent advances in the understanding of ...
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The heart is highly energy dependent with most of its energy provided by mitochondrial oxidative phosphorylation. Mitochondria also play a role in many other essential cellular processes including metabolite synthesis and calcium storage. Therefore, maintaining a functional population of mitochondria is critical for cardiac function. Efficient degradation and replacement of dysfunctional mitoch...
متن کاملMyocardin-related transcription factor-A: mending a broken heart.
Ventricular remodeling following myocardial infarction (MI) is a complex process driven by the response of both the myocytic and the nonmyocytic components of the heart to dynamic mechanical and neurohumoral stimuli. Despite the advent of reperfusion therapy and the administration of drugs slowing the progression of heart failure, many patients experiencing a MI undergo a progressive decline in...
متن کاملMenDing a Broken Heart: steM Cells anD CarDiaC repair
Cardiovascular disease (CVD), which includes hypertension, coronary heart disease (CHD), stroke, and congestive heart failure (CHF), has ranked as the number one cause of death in the United States every year since 1900 except 1918, when the nation struggled with an influenza epidemic. In 2002, CVD claimed roughly as many lives as cancer, chronic lower respiratory diseases, accidents, diabetes ...
متن کاملMending a growth-restricted fetal heart: should we use glucocorticoids?
Clinical and experimental studies suggest that the growth-restricted fetus at increased risk of impaired cardiovascular function that likely contributes to both increased mortality rate and in survivors, to cardiovascular dysfunction apparent in childhood and later life. Fetal growth restriction is also associated with a high risk of preterm birth. Accordingly, the growth-restricted fetus is mo...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2016
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.115.306820